Materie prime per cosmetica Polinesia Fr.

Tamanu Oil

Scientific Name(s): Calophyllum inophyllum L. (Clusiaceae).

Common Name(s): Alexandrian laurel , Tamanu oil , tamanu , ti , kamanu , kamani , fetau , dolno , dilo

Uses

Tamanu oil has been used traditionally as a local medicine, and is sometimes considered the African, Asian,Polynesian, and Pacific Rim panacea. All parts of the plant (ie, bark, leaves, seeds) have been used medically as antiseptics, astringents, expectorants, diuretics, and purgatives. The oil possesses antimicrobial and antiviral activity.

Dosing

None suggested because of lack of clinical data.

Contraindications

None.

Pregnancy/Lactation

Avoid use. Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

None well documented.

Adverse Reactions

There are case reports in scientific literature of allergic contact dermatitis from tamanu oil. Tamanu oil may cause hypersensitivity reactions in patients with an existing allergy to plants in the Clusiaceae family.

Toxicology

Review of the scientific literature reveals little to no toxicity data on the plant.

Botany

The genus Calophyllum consists of approximately 130 species. C. inophyllum is indigenous to Southeast Asia, and is also found in Southern India, Sri Lanka, and throughout the islands of Melanesia and Polynesia. It is a tropical evergreen plant that can grow up to 30 m in height. The trunk is typically thick and the bark is dark to grayish brown.

Tamanu Oil Uses, Benefits & Dosage - Drugs.com Herbal Database http://www.drugs.com/npp/tamanu-oil.html

The plant has dark green oval leaves and white flowers with a yellow center. The mature green fruit is inedible and is about the size of an apricot. The plant prefers salty and sandy soil.

History

Tamanu has been used traditionally as a local medicine, and is sometimes considered to be the African, Asian, Polynesian, and Pacific Rim panacea. All parts of the plant (bark, leaves, seeds) have been used medicinally as antiseptics, astringents, expectorants, diuretics, and purgatives. The oils of the seed and root have been used to treat wounds and scabies. In Pacific island folk medicine, the oil has been topically applied to treat various ailments such as cuts, scrapes, burns, insect bites and stings, abrasions, acne and acne scars, psoriasis, diabetic sores, anal fissures, sunburn, dry or scaly skin, blisters, eczema, herpes sores, and to reduce foot and body odor. The oil has also been topically applied to the neck area to treat sore throat. The oil is valued for its analgesic and pain-relieving

properties and has been used to treat neuralgia, rheumatism, and sciatica. The oil is used in Chinese traditional medicine to treat rheumatism, skin infections, wounds, leprous nephritis, pain, eye diseases, and inflammation.

Chemistry

Xanthones isolated from the plant have antibacterial activity, and 4-phenyl coumarins obtained from its leaves may have antitumor-promoting activity. Several triterpenes, flavonoid glycosides, neoflavonoids, pyranoamentoflavone, and other bioactive compounds have been isolated from the plant. Two isomeric benzodipyranone derivatives have been isolated from the leaves.

The root bark contains the xanthones caloxanthone A, B, C, and D. Caloxanthone E was isolated from the root heartwood of the plant.

Two epimers, inophynone and isoinophynone, were isolated from the leaves of the plant, as well as friedelin,canophyllol, and canophyllic acid.

Four pyranocoumarin derivatives have been isolated from the seeds of the plant, designated as inocalophyllins A (1), B (2), and their methyl esters (3, 4). Ten 4-phenylcoumarins have also been isolated from the plant.

The anti-HIV activity of the following coumarins has also been reviewed and includes: calophyllolide, inophyllum P(Soullatrolide), inophyllum B, inophyllum C, and inophyllum E.

Uses and Pharmacology

Review of the scientific literature reveals mostly animal studies evaluating the efficacy of tamanu oil.

 

Antibacterial activity

In vitro analysis

At a dose of 20 mcg/disc in an agar well diffusion assay, caloxanthone A, calophynic acid, brasiliensic acid, inophylloidic acid, calophyllolide, and inophyllum C and E, were found to inhibit Staphylococcus aureus but not Vibrio anguillarium , Escherichia coli , and the yeast Candida tropicalis .

 

Antiviral activity

In vitro analysis

Various chemical components of C. inophyllum have been examined for antiviral activity. Inophyllums are considered novel nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. Inophyllum B was active against HIV-1 in cell culture with an IC50 of 1.4 millimoles (mM). Inophyllum P (soullatrolide) also has anti-HIV Tamanu Oil Uses, Benefits & Dosage - Drugs.com Herbal Database http://www.drugs.com/npp/tamanu-oil.html activity.

 

Anticancer activity

Animal studies

The isolation of 10 natural 4-phenylcoumarins from C. inophyllum inhibited (except inophyllum C and calocoumarin C) Epstein-Barr virus early antigen in Raji cells. Calocoumarin-A exhibited the most potent inhibitory activity in a 2-stage mouse skin carcinogenesis test.

 

Dosage

None suggested due to lack of clinical data.

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

None well documented.

Adverse Reactions

There are case reports of allergic contact dermatitis from tamanu oil. Tamanu oil may cause hypersensitivity reactions in patients with an existing allergy to plants in the Clusiaceae family.

Toxicology

Review of the scientific literature reveals little to no toxicity data on the plant.

TAINOA (Cassvtha filiformis)

is a parasitic vine, adhering to the host by suckers. Stems are very long, slender, brown, yellowish brown or greenish, twining and mattedtogether, with numerous branches forming a web of leafless cords over grasses or bushes. Flowers, born on short spikes, are small and stalkless. Perianthsegments are unequal, the outer small and rounded, and the inner ones much longer, oblong or oval in shape. Stamens are 9, in 3 rows, anthers are all2-celled, 2 outer rows introrse, the inner row extrorse. Ovary is superior, 1-celled. Fruits: nearly spherical, smooth, fleshy and about 7 mm in diameter.

 

Constituents

- Contains an alkaloid (0.1 %) identical to laurotetanine, described under Litsea sebifera.

- Three major aporphine alkaloids: actinodaphnine, cassythine, dicentrine)

- Study yielded three new compounds: two alkaloids, cassyformine and filiformine, and a lignan along with 14 known compounds.

- Yields an abundant mucilage.

Properties

- Sweet and mildly bitter tasting, astringent, diuretic, antiphlogistic , anticontusion, laxative, cooling, tonic, and alterative.

- Laurotetanine can cause cramps, and in sufficient doses, death.

Parts

· Entire plant.

· Collect from May to October.

· Rinse, cut into pieces, dry under the shade, compress before using.

Uses

· Used for constipation, dysentery, hemoptysis, epistaxis, acute conjunctivitis, furuncles, cold, fever, and headaches.

· Decoction of dried material used for nephritic-edema, urinary lithiasis and infections, hepatitis, hepatic fever among infants, cold-fever among infants, headaches, multiple furuncles.

· Poultice of pounded fresh material applied to furuncles; or, decoction applied as external wash to same.

· Decoction of fresh plant used to hasten parturition.

· In India, the powdered plant, mixed with sesame oil, used to strengthen the hair. Whole plant used as alterative in bilious disorders and piles.

· Used by Brahmins, in a mixture of butter and ginger, for cleansing of inveterate ulcers

· Sanskrit writers describe it as a tonic and alterative, and its power of increasing the secretion of semen.

· In Maritius, decoction used for rachitic infants.

· In African folk medicine, used to treat cancer and African trypanosomiasis.

· In southern Africa, used for washing the hair, destroying vermin, and promoting hair growth.

· In Senegambia, used for urethritis.

· In Cochin-China used as antisyphilitic.

Studies

Chemical Constituents / Antiplatelet aggregation activity: Study yielded three new compounds,

incuding cassyformine (an aporphine alkaloid), filiformine (an oxoaporphine alkaloid) and a lignan. Some isolates exhibited significant antiplatelet aggregation activity.

Aporphines / Anti-cancer / Anti-trypanosome: (1) Alkaloids from Cassytha filiformis and related aporphines: Antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases: Study showed isolated aporphines to possess in vitro cytotoxic properties and exhibited interactions with DNA which may partly explain the effect on cancer cells and on trypanosomes. Study isolated six aporphines, and analyzed the in vitro cytotoxic properties of four on different cancer and non-cancer cell lines. Major alkaloids - actinodaphnine, cassythine and dicentrine – showed antitrypanosomal properties in vitro.

Ocoteine / Alpha1 Adrenoceptor Blocking Agent: Study isolated ocoteine and was found tob e an alpha-1 adrenoceptor blocking agent in rat thoracic aorta. At high concentrations, it also blocks 5-HT receptors.

Vasorelaxant / Alkaloids / Flavonoids: Study yielded two aporphine alkaloids, isofiliformine and cassythic acid along with 22 known compounds from the whole herb of Cf. Cassythic acid, cassythine, neolitsine and dicentrine showed potent vasorelaxing effects on precontracted rat aortic preparations.

Toxicity Studies: Study of aqueous extract of C. filiformis in normal therapeutic doses is not likely to produce severe toxic effects on some organs, hematologic and biochemical parameters in rats.

Diuretic Activity: Study of the aqueous and alcoholic extracts of Cuscuta reflexa and Cassytha filiformis exhibited significant diuretic activity and marked increase in Na and K excretion. The diuretic effect was higher with the C filiformis extract.

Monoi ( Coconut oil with Gardenia tahitiensis flowers , Tiarè )

datasheet MONOI
All about the MONOI oil and his use
monoi studio.pdf
Documento Adobe Acrobat [1.8 MB]

   Marine AI TAMCORE1

Nature and composition

is a marine active ingredient obtained by controlled co-extraction of coral zooxantella sp. (photosynthetic unicellular algae)  and of giant clam zooxantella  (Tridacna sp.), both from Pacific Ocean , with a mixture of ethanol /water and glycol propylene .

The production process require organism (corals and giant clams ) farmed by aquaculture process and followed by extraction of their symbiotic unicellular algae . At the end, the zooxantella strain is massively    produced and concentrated in lab bioreactor.   

 

CTFA name: Ethanol (and) Water (or) Glycol propylene (and) Symbiodinium sp. (zooxantella) algae

extract (and) Acropora sp.(coral)  extract

 

Mode of action: In light of its composition in mycosporine-like amino acids (MAAs) , GFPs (green fluorescent protein) and unknown cnidocist peptides used to protect wild coral by marine predator , AI TAMCORE1 is an active ingredient of choice for providing UV-absorbing screen and besides repair of UV-induced damage of DNA and accumulation of carotenoids and detoxifying enzymes or radical quenchers and antioxidants. Various coral peptides compound have a role as skinprotective and  antinflammatory  compounds .TAMCORE1 can be a good chance for an after bite of mosquitoes and marine jelly fish. Good test show a synergic activity for skin treatment with the Tamanu plant oil (Calophyllum inophyllum)

   Marine HUASPE1

Nature and composition

is a marine active ingredient obtained by controlled co-extraction of a particular strain of sponge and holothurians from Pacific Ocean zone , with a mixture of ethanol /water and glycol propylene .

The production process require collection and sponge farming followed by drying and chemical extraction with a mixture of ethanol /water and glycol propylene .

 

 

CTFA name: Ethanol (and) Water (or) Glycol propylene (and) sponge (and) holoturia extract

 

Mode of action: In light of sponge life to produce antimicrobial compound used as mechanisms

to combat wild microfouling , the marine extract contain preservative peptides very active against bacteria like Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus and fungi strain like Aspergillus

niger . It can be used as preservative compound for cosmetic topic use  . Also it contain carotenoids and Manoalide as anti-oxidant agents (anti ages)  . It is a source of new sterols like 14αmethylsterol  to be used to protect human cell membranes.

marine HYPBOBE1

Nature and composition

is a marine active ingredient obtained by controlled co-extraction of two particular strain of tropical marine macro algae from Pacific Ocean island  .

The production process require collection and alghe farming followed by drying and chemical extraction with a mixture of ethanol /water and glycol propylene .

 

 

CTFA name: Ethanol (and) Water (or) Glycol propylene (and) HYP red algae extract (and) DIC red algae extract

 

Mode of action: These marine compound are rich of marine Flavonoids that have antioxidant activity . To be used  in anti-allergic, antioxidant (anti age) like free-radical, superoxide anion radical scavenging, reducing activity, and inhibition of lipid peroxidation. According with the antioxidant DPPH test ,the marine HYPBOBE show 120 more activity of Tocopherol .  It’s reported that these algae contain also a UV-absorbing compounds.

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